Trial data has shown that the Pfizer-BioNTech and Moderna vaccines are safe and generally well tolerated. An imbalance of unsolicited adverse events in the skin and subcutaneous tissue disorders was also observed between the vaccine group (1.1%) and placebo group (0.6%). A rare coronavirus vaccine side effect that some people have experienced, however, is a lump in the armpit of the arm in which they've been vaccinated. However, in a very small number of cases, an allergic . Unsolicited AEs were collected during the 28 days after each dose. Thank you for taking the time to confirm your preferences. Materials in this section are updated as new information and vaccines become available. Nodules are defined as the presence of a palpable, firm, discrete or well-demarcated soft tissue lump at the site of immunisation in the absence of heat, erythema (redness) or signs of abscess. The frequency and severity of systemic reactions was higher after dose 2 than dose 1 (86.1% vs 68.5%). Please refer back to the website to ensure all reference information is current and up-to-date. According to the Centers for Disease Control and Prevention (CDC), the expected vaccine side effectsfever, chills, tiredness, headache, and pain or swelling of the injected armare a normal response to your body building immunity against the virus. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE. Multiple studies have found that COVID-19 vaccines, including boosters, are safe, and that adverse reactions are rare. If you experience soreness, redness, swelling, or an itchy rash at the injection site about a week after getting the booster, you likely have COVID arm. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. No specific safety concerns were identified among vaccine recipients aged 6 months5 years. The majority of solicited systemic reactions occurred within the first 2 days after each, persisting for a median of 2 days.
Injection site reactions - The Melbourne Vaccine Education Centre (MVEC) The majority of these events of lymphadenopathy occurred in the arm and neck region. Skin reactions to COVID-19 and its vaccines. b mild: no interference with activity; moderate: some interference with activity; severe: prevents daily activity; Grade 4: emergency room visit or hospitalization, Systemic reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients. All Rights Reserved. } 8600 Rockville Pike Epub 2023 Jan 2. In a CDC report on the Moderna vaccine, the agency said that the swelling of lymph nodes, also known as lymphadenopathy, can occur in either the arm or the neck. In Victoria reports can be made to SAEFVIC. Based on the CDC's findings, this vaccine side effect is quite rare. If you are currently eligible to get vaccinated, click the Find COVID-19 Vaccines button to find a vaccination location and schedule an appointment with the specific vaccine provider or pharmacy. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Administer vaccines that may be more likely to cause a local reaction (e.g., tetanus-toxoid-containing and PCV13) in different limbs, if possible. For more information, see the manufacturers website. Adverse events in the vaccine group were similar in nature and incidence to those in the placebo group, with the exception of higher incidence of injection site erythema in the vaccine group compared to the placebo group (1.3% vs 0.2%) and COVID-19 in the placebo group compared to the vaccine group (5.5% vs 3.1%). Overall, the median onset of local reactions in the vaccine group was 1 day after either dose, with a median duration between 2 and 3 days. A detailed discussion of strategies to reduce procedural pain can be found here.
Allergic Reactions after COVID-19 Vaccination | CDC The following were higher in the placebo group compared with the vaccine group by at least 1%: upper respiratory tract infection (12.2% vs 10.3%), COVID-19 (4.9% vs 3.5%), and otitis media (3.7% vs 2.6%). Doctors say this is a normal side effect of the COVID vaccine. There are several reasons why your arm may be sore after getting vaccinated, including your body's immune response and inflammation in your muscle. What Are the Side Effects of the COVID-19 Vaccine? CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Epub 2022 Jul 20. "Reports of lymphadenopathy were imbalanced with 1.1 percent of persons in the vaccine group and 0.6 percent in the placebo group reporting such events," the CDC notes. If you get the Moderna COVID-19 vaccine, there is a small chance that you could develop a skin reaction. Axillary swelling or tenderness was reported more frequently post dose 1 (23.2%) than dose 2 (21.0%). Systemic reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients. The Johnson & Johnson vaccine or the recently approved Novavax have not been associated with this side effect. An imbalance of unsolicited adverse events in the skin and subcutaneous tissue disorders was also observed between the vaccine group (2.4%) and placebo group (1.0%). Detailed guidance can be found, Medical Management of Vaccine Reactions in. Some patients are reporting a lump in their armpit after getting the COVID vaccine. If you havent experienced COVID arm before after getting your first shot, youre even less likely to get it now. We take your privacy seriously. Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases. Pain at the injection site was more common post Dose 2 (94.8%) than Dose 1 (93.1%). An official website of the United States government. COVID arm is a delayed hypersensitivity skin reaction that occurs on or around the injection site. An alternative childhood vaccine schedule is getting a child vaccinated on a schedule different from what the CDC recommends. Injecting vaccines rapidly without aspiration, Using tactile stimulation (rubbing/stroking near the injection site before and during injection), Distracting the patient (done by either the parent or clinician), Having the patient seated rather than lying down. If possible, administer COVID-19 vaccine and other reactogenic vaccines (e.g., MenB, Tdap) in different limbs. a Fever Grade 3: 39.0 40.0C or 102.1 104.0F; Grade 4: >40.0C or >104.0F Injecting the most painful vaccine last when multiple injections are needed can decrease the pain associated with the injections. Their risk of vaccine-preventable disease (e.g., during an outbreak or occupational exposures). Common Infections. Fever was more common after the second dose (12.1%) compared to the first dose (2.5%). Very rarely, a nodule may persist and become symptomatic for the vaccinee (see rare or persisting subcutaneous nodules below). Adults and children may have some side effects from a COVID-19 vaccine, including pain, redness or swelling at the injection site, tiredness, headache, muscle pain, chills, fever, and nausea. The COVID-19 vaccines are beginning to significantly slow the spread of the virus, but the Pfizer and Moderna and vaccines are having an unforeseen consequence for breast cancer doctors. One case of Bells palsy in the vaccine group was considered a serious adverse event. Injection site reactions are common after vaccines or treatments delivered through a shot. Lymphadenopathy occurred in the arm and neck region and was reported within 2 to 4 days after vaccination. While not impossible, it is less likely to occur with a booster shot if you havent experienced it before.
Covid Arm: Causes, Safety, Treatment, and More - Healthline Deep intramuscular (IM) injection for IM vaccines should be considered to minimise the risk of potential recurrence of a nodule. In the meantime, you can get relief with warm compresses and over-the-counter pain medications. A higher frequency of unsolicited adverse events was reported in the vaccine group compared to the placebo group (29.6% vs 25.1%). Get the details on dosage, side effects, cost, and more. The Society of Breast Imaging reports that 11.6% of patients who received Moderna's COVID-19 vaccine had swollen lymph nodes after the first dose, and 16% after the second dose. In general, unsolicited adverse events experienced in the vaccine group were similar in nature and incidence to those in the placebo group. Swelling, redness (erythema), pain and itch at the site of injection can be a common side effect from any vaccine. A new survey takes the worst traffic, road conditions, and infrastructure into consideration. Cebeci Kahraman F, Sava Erdoan S, Akta ND, Albayrak H, Trkmen D, Borlu M, Arca DA, Demirba A, Akbayrak A, Polat Ekinci A, Gkek GE, elik HA, Taolar MK, An , Temiz SA, Hazinedar E, Ayhan E, Hzl P, Solak E, Kl A, Ylmaz E. J Cosmet Dermatol. E, et al Nodule at injection site as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation, Vaccine 2004 (22): 575-585, Silcock, R. et al Subcutaneous nodules following immunization in children; in Victoria, Australia from 2007 to 2016, Vaccine 2020 (38): 3169-3177, Silcock, R. et al Subcutaneous nodules: an important adverse event following immunization, Expert Review of Vaccines 2019 (18): 405-410, Bergfors, E. Lundmark, K. Kronander, U. No other systemic grade 4 reactions were reported. -, Vasireddy D, Atluri P, Malayala SV, Vanaparthy R, Mohan G. Review of COVID19 Vaccines Approved in the United States of America for Emergency Use. Any treatments would need to be provided following medical review and can include topical corticosteroids or dressings to protect the area from rigorous scratching. There were 2 SAEs among 2 participants in the placebo group (affective disorder and COVID-19). Learn more. Epub 2023 Jan 13. The frequency of local reactions was higher in the older age group (ages 2 to 5 years) than the younger age group (ages 6-23 months) (73.4% vs 54.4% after dose 2). If you do experience anaphylaxis symptoms or symptoms of myocarditis after getting COVID vaccine, you should seek immediate help. 3. Pain at the injection site was the most frequent and severe reported solicited local reaction among vaccine recipients. Axillary swelling or tenderness was reported more frequently in the younger age group than the older age group (16.0% vs 8.4% after dose 2). if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { In the younger age group, the most common serious adverse event occurring at higher rates in the vaccine group than the placebo group was febrile seizure (3 cases in vaccine group vs. 0 cases in placebo group). To relieve symptoms, experts recommend taking an . It is mostly associated with mRNA vaccines like Moderna and Pfizer. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology. We adhere to structured guidelines for sourcing information and linking to other resources, including After leaving a vaccination provider site, if you think you or your child might be having a severe allergic reaction, seek immediate medical care by calling 911. Most of the known reactions have occurred with Moderna. Allergic reactions after COVID-19 vaccination. You can review and change the way we collect information below. Serious adverse events were defined as any untoward medical occurrence that resulted in death, was life-threatening, required inpatient hospitalization or prolongation of existing hospitalization, or resulted in persistent disability or incapacity. They are often reported by parents to feel like a pea size lump under the skin. Pain at the injection site was the most frequent and severe reported solicited local reaction among vaccine recipients. (2022). The main imbalances between the vaccine and placebo groups were general disorders and administration site conditions, consistent with the known reactogenicity profile of the vaccine. *Based on age. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.
Injection site reactions after COVID-19 mRNA vaccination COVID-19 Vaccination Locations on VaccineFinder | CDC Nodules are defined as the presence of a palpable, firm, discrete or well-demarcated soft tissue lump at the site of immunisation in the absence of heat, erythema (redness) or signs of abscess. (Table 9), a Severe: prevents daily activity; Grade 4: emergency room visit or hospitalization, b Severe: any use of prescription pain reliever or prevents daily activity; Grade 4: emergency room visit or hospitalization, c Severe: prevents daily activity and requires medical intervention; Grade 4: emergency room visit or hospitalization. aluminium), local inflammatory reactions or immune-mediated responses have been implicated as possible contributing factors. (2022). [emailprotected]. The AstraZeneca vaccine Vaxzevria is a vaccine against COVID-19. Cookies used to make website functionality more relevant to you. In the placebo group serious adverse events, 1 participant experienced an abdominal wall abscess and 1 participant with rhinovirus infection and asthma. People behind the wheel of this model have the highest rate of reckless driving infractions. Administer vaccines that are known to be painful when injected (e.g., MMR, HPV) last. a Fever Grade 3: 39.0 40.0C or 102.1 104.0F; Grade 4: >40.0C or >104.0F People sometimes faint after medical procedures, including vaccination. Any severe skin reaction after the vaccine is also very rare. Usually, the symptoms of COVID arm resolve on their own. Epub 2022 Jul 19. COVID arm: A reaction to the Moderna vaccine. Functional angiopathies (chilblain-like lesions, erythromelalgia) may also be observed. a Pain grade 3: any use of prescription pain reliever or prevented daily activity; grade 4: required emergency room visit or hospitalization. (a) Immediate (type I) allergic reactions to COVID19vaccine components, polyethylene glycols (PEG) and crossreactive polysorbate 80, can lead to mast cell degranulation causing urticaria, angiooedema and anaphylaxis. SARSCoV2 vaccines the biggest medical research project of the 21st century. Each vaccine has a recommended administration route and site. Federal government websites often end in .gov or .mil. If you experience soreness, redness, swelling, or an itchy rash at the injection site about a week after getting the booster, you likely have COVID arm. Learn whether a previous smallpox vaccine can protect you against the current monkeypox outbreak. . After dose 1, the younger age group reported pain more frequently than the older age group (86.9% vs 74.0%); a similar pattern was observed after dose 2 (90.1% vs 83.4%). You might notice a lump behind your ear when you get sick. Appropriate measures should be taken to prevent injuries if a patient becomes weak or dizzy or loses consciousness, including: To receive email updates about this page, enter your email address: We take your privacy seriously. 2021 Jul;85(1):46-55. doi: 10.1016/j.jaad.2021.03.092. A higher frequency of unsolicited adverse events after any dose was reported in the vaccine group (20.5%) compared to the placebo group (15.9%). COVID arm is a relatively rare occurrence, which should not be confused with the early onset arm reactions caused by many vaccines. Since the COVID-19 vaccines are new, we dont know definitively what exact mechanism triggers COVID arm symptoms. Injection site redness and swelling following either dose was reported slightly less frequently and was more common after dose 2 than dose 1. And for more up-to-date COVID news delivered right to your inbox, sign up for our daily newsletter. The most common reported side effect following vaccination is pain at the injection site. It's not yet approved for use in the United States. of our COVID-19 coverage. J Clin Med Res 2021; 13: 204213. No grade 4 local reactions were reported. A child with a long-standing, intensely itching subcutaneous nodule on a thigh: an uncommon (?) All rights reserved. COVID vaccinations kicked off in December in the U.S., and they have been steadily reaching more and more people as the weeks have gone on. Elyoussfi DS, et al. Some of the evidence-based strategies for reducing procedural pain in children can also be used to help prevent distress and alleviate fear in adults. It wont escalate to a life threatening condition or serious allergic reaction and is not associated with anaphylaxis. aGrade for fever: Any 38.0C; grade 3=39.6-40.0C; grade 4=> 40.0C. Your immune system has already indicated its responding robustly. . Even though its not serious, COVID arm can be uncomfortable. Moving your arm and using a cool compress should help soothe the pain. if( navigator.sendBeacon ) { COVID-19 vaccine has been associated with enhanced local/injection site reactions l (e.g., pain, swelling, redness). (2022). FOIA e Chills Grade 3: prevented daily activity and required medical intervention; Grade 4: required emergency room visit or hospitalization. Wei N, et al. If possible, administer COVID-19 vaccine and other reactogenic vaccines (e.g., MenB, Tdap) in different limbs. The .gov means its official. Typically, an injection-site reaction is considered to be any pain, swelling, rash, bleeding, or redness that occurs at the site of an injection, although, serious reactions can occur (see sidebar 1 ). If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. COVID-19 is a life threatening condition, and the vaccine is highly protective against the virus SARS-CoV-2, which causes COVID-19. Let's discuss how this can affect different ages and how to, The most commonly reported side effect from the vaccine is injection site reaction. Subcutaneous injections can lead to localised cellulitis, granuloma formation and abscess. You will be subject to the destination website's privacy policy when you follow the link. No other systemic grade 4 reactions were reported. c Axillary swelling or tenderness was collected as a solicited local adverse reaction (i.e. Why does this happen? Thank you for taking the time to confirm your preferences.
Frequently Asked Questions about COVID-19 Vaccination | CDC Type IV hypersensitivity reactions may be observed, including delayed large local skin lesions ("COVID arm"), inflammatory reactions in dermal filler or previous radiation sites or even old BCG scars, and more commonly morbilliform and erythema multiforme-like rashes. A 2021 case report showed that the Pfizer-BioNTech vaccine might also cause COVID arm but appears less likely to do so. (c) Mechanism of molecular mimicry caused by genetic similarities of SARSCOV2 spike protein components to endogenous crossreactive human antigens. Our content is fact checked by our senior editorial staff to reflect accuracy and ensure our readers get (2022). Prepare each injectable vaccine using a separate syringe.
COVID-19 Vaccines Can Cause Lumps That Mimic Breast Cancer 2022 Dec;36(12):e979-e981. Redness and swelling were slightly more common after dose 2. Where possible, avoid vaccination at a site of an existing nodule. While this might seem strange or alarming, doctors want to assure patients that it's actually totally normal, even though it's on the rare side as far as side effects go. The most commonly reported unsolicited adverse events after any vaccine dose were injection site lymphadenopathy (4.3%) and headache (2.2%). Injection site reactions. COVID arm: Very delayed large injection site reactions to mRNA COVID vaccines. var payload = 'v=1&tid=UA-72659260-1&cid=88c0d158-dd67-4ce6-b7fb-896573127f51&t=event&ec=clone&ea=hostname&el=domain&aip=1&ds=web&z=4068651850916361813'.replace( 'domain', location.hostname ); COVID arm is a rare reaction. Recently, people who have been vaccinated are sharing stories online about feeling lumps in their armpits, which might seem like cause for concern, but is in fact, to be expected. Injection site reactions will go away on their own. COVID arm is thought to be an immune system reaction. This system administers vaccines by creating a narrow stream capable of penetrating the skin. They usually resolve spontaneously without treatment or investigation. sharing sensitive information, make sure youre on a federal Incidence of lymphadenopathy was higher in the vaccine group (0.7%) than the placebo group (<0.1%). Skin reactions to COVID-19 vaccines. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Coronavirus (COVID-19) Update: FDA authorizes emergency use of Novavax COVID-19 vaccine, adjuvanted. } ); If you didnt get it before, youre less likely to get it after a booster shot. The proportions of participants who reported at least one serious adverse event were 0.5% in the vaccine group and 0.2% in the placebo group. Bells palsy was reported by three vaccine recipients and one placebo recipient. ACS Central Sci 2021; 7: 512533. What We Know About the Side Effects of Pfizers COVID-19 Vaccine, What You Should Know About the AstraZeneca COVID-19 Vaccine, COVID-19 Vaccine Side Effects: What to Know Now, Monkeypox and the Smallpox Vaccine: Your Questions Answered. But any time you experience skin symptoms, its a good idea to speak with your doctor. Catal A, Muoz-Santos C, Galvn-Casas C, Roncero Riesco M, Revilla Nebreda D, Sol-Truyols A, Giavedoni P, Llamas-Velasco M, Gonzlez-Cruz C, Cubir X, Ruz-Villaverde R, Gmez-Armayones S, Gil Mateo MP, Pesqu D, Marcantonio O, Fernndez-Nieto D, Roman J, Iglesias Pena N, Carnero Gonzalez L, Tercedor-Sanchez J, Carretero G, Masat-Tic T, Rodrguez-Jimnez P, Gimenez-Arnau AM, Utrera-Busquets M, Vargas Laguna E, Angulo Menndez AG, San Juan Lasser E, Iglesias-Sancho M, Alonso Naranjo L, Hiltun I, Cutillas Marco E, Polimon Olabarrieta I, Marinero Escobedo S, Garca-Navarro X, Caldern Gutirrez MJ, Baeza-Hernndez G, Bou Camps L, Toledo-Pastrana T, Guilabert A. Br J Dermatol. After you get a vaccine shot in your upper arm to protect yourself against the flu, COVID-19, or another disease, there's a chance you'll feel some soreness where you got jabbed. There were no grade 4 local reactions reported. Be aware of symptoms that precede fainting (e.g., weakness, dizziness, pallor). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Cazzato G, Ambrogio F, Pisani MC, Colagrande A, Arezzo F, Cascardi E, Dellino M, Macorano E, Trilli I, Parente P, Lettini T, Romita P, Marzullo A, Ingravallo G, Foti C. Vaccines (Basel). -, Blumental S, Debr P. Challenges and issues of antiSARSCoV2 vaccines. urticaria, angio-oedema and anaphylaxis) likely due to allergy to ingredients may rarely occur but can be severe. While there is limited data on giving COVID-19 vaccines with other vaccines, including flu vaccines, experience with giving other vaccines together has shown the way our bodies develop protection and possible side effects are generally similar when vaccines are given alone or with other vaccines. Use combination vaccines (e.g., DTaP-IPV-HepB or DTaP-IPV/Hib) to reduce the number of injections, when appropriate. Of these, 21 developed post-vaccination injection-site reactions. Its symptoms appear several days to a week after the first or second vaccination. The following unsolicited adverse events were higher in the vaccine group compared with the placebo group by at least 1%: injection site lymphadenopathy (1.4% vs 0.2%); croup (1.3% vs 0.3%); diarrhea (3.2% vs 2.2%). Cutaneous findings following COVID‐19 vaccination: Review of world literature and own experience. (2021). xhr.send(payload); Although pain from injections is, to some extent, unavoidable, there are some things that parents and health care providers can do to help prevent distress and decrease fear. b Grade 3: prevents daily activity; Grade 4: emergency room visit or hospitalization for severe pain at the injection site. Among vaccine recipients, the median onset of systemic reactions was 1 to 2 days after either dose, with a median duration of 2 days. (2021).
Why Baby Has A Hard Lump On Leg After Vaccination - BabyGaga A COVID-19 vaccine can cause enlarged lymph nodes in your armpit or near your collarbone on the side of your body where you received the injection. Axillary (or groin) swelling or tenderness was the second most frequently reported local reaction. Disclaimer. Read on to find out more about this reaction and for another heads-up about vaccinations, know that This COVID Vaccine Side Effect Could Show Up a Week After Your Shot. Keep in mind that COVID arm is relatively rare and never dangerous. Subcutaneous injection can happen inadvertently ( figure 1 ), affecting efficacy of vaccination and potentiate local adverse events. The COVID19 vaccine development: a pandemic paradigm. Nodules can occur following any vaccine. Histopathological Patterns of Cutaneous Adverse Reaction to Anti-SARS-CoV-2 Vaccines: The Integrative Role of Skin Biopsy. The most common solicited systemic adverse reactions after any dose were irritability/crying and fatigue for participants 636 months and 37 months5 years, respectively. Currently available information is insufficient to determine a causal relationship with the vaccine. No serious adverse events were considered by the FDA as related to vaccine. The lymphatic system is home to your immune system; so when you get checked out for a cold or strep throat or flu, your doctor will feel your neck area. Intensified itching and a change in size of the nodule has been reported when a child is unwell with a viral infection or even following subsequent vaccinations given at a different anatomical site. If you catch strep throat or an ear infection, the lymph nodes behind your ears can become swollen and inflamed. Unlike an immediate allergic reaction, this delayed reaction is not serious and does not mean you should avoid getting a booster shot. Doctors and the CDC say this coronavirus. (Table 10, Table 11).
What Causes COVID Arm? | Cedars-Sinai Ann Clin Lab Sci. If you experience swelling of your lips, eyes, or tongue, that could be an allergic reaction to the vaccine. Onset is typically around one week after vaccination. Vaccine recipients reported higher rates of local reactions after dose 2 than dose 1. (2021). Provide supportive care and take appropriate measures to prevent injuries if such symptoms occur. It typically occurs around one week after the first or second shot vaccination. Vaccine recipients reported similar rates of local reactions after dose 1 and dose 2, but slightly lower after dose 3. 2022 Galvanized Media. Sometimes, your doctor or vaccination provider may recommend alternating arms if you had a strong skin reaction to your first vaccine. 2022 Sep;21(9):3692-3703. doi: 10.1111/jocd.15209. Fever, headache, abdominal pain, diarrhea, nausea, and vomiting can happen after live typhoid vaccine. (2021). Local reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients.
You May Notice a Lump in These 2 Places After Your Vaccine - Best Life If you have itching, swelling, or tenderness at the injection site in the days after getting either dose of the vaccine, don't panic. Unsolicited adverse events were collected during the 28 days after each dose. Deviation from the recommended route may reduce vaccine efficacy or increase local adverse reactions. Unauthorized use of these marks is strictly prohibited. The vaccines often cause swelling in the armpit or underarm that can mimic the lumps associated with breast cancer, causing some women undue concern. There were 2 SAEs among 2 recipients (obstructive nephropathy and suicide attempt). No grade 4 local reactions were reported.
New Vaccine Side Effect "COVID Arm" Striking Patients, Say Doctors COVID arm: Delayed hypersensitivity reactions to SARS-CoV-2 vaccines misdiagnosed as cellulitis. There was one report of grade 4 headache and one report of grade 4 nausea/vomiting, both after dose 2. Please enable it to take advantage of the complete set of features! Do NOT mix more than one vaccine in the same syringe in an effort to create a combination vaccine..